Cannabis reactions differences in men and women

Recreational Weed

Much can be explained by the influence of hormones

Marijuana has been a purely male subject for decades. Probably a lot can be explained by the fact that women are less prone to risky behavior and not associated with “dangerous drugs” because of the propaganda. But maybe it is also because the weed acts differently on men and women.

A recent study published in the journal Drug and Alcohol Addiction shed light on the role of the female sex hormone estrogen in perceiving the effect of marijuana. Experiments on rats have shown that estrogen enhances the effects of THC. This is why women experience greater high effects especially in the days before ovulation. This is partly even good because taking the “medicine” on critical days makes pain, cramps, irritability, and other unpleasant symptoms easier.

On the other hand, these hormonal fluctuations associated with the menstrual cycle led scientists to be reluctant to test new drugs on women. And that includes cannabis. Men have been in clinical trials of substance mostly.

Another feature of the female body is the rapid development of tolerance to THC. Women need more doses than men to achieve the desired effect over time. There may be a danger to women like addiction and withdrawal when trying to refuse to use.

But marijuana is much more suitable for women than men as an aphrodisiac. It is known that high doses of THC can reduce appetite and make it more difficult to achieve orgasm in men, although small and medium doses of marijuana certainly help in bed. Ladies are also encouraged to keep their dosage and choose THC-reduced varieties where possible but high doses also stimulate female sexuality to a lesser extent.

Another study investigated the negative effects of marijuana on visual and spatial memory. While men’s regular smokers (at least 29 times a month) and irregular smokers (once a month) scored the same results in the tests, there were significant differences among women. Those who used marijuana regularly scored the worst in visual and spatial memory tests.

All of this underscores the fact that cannabis acts differently on different people, so do not try to be equal to others, determine the frequency of use and dosage for yourself, and do not forget about the risks.

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The content on this channel does not form a professional opinion, recommendation, substitute for consulting a specialist, or receiving medical advice. Cannabis is a dangerous drug, as defined in the Dangerous Drugs Ordinance, for all that assumes. Four Hundred and Twenty does not encourage or recommend consuming any substance and will not be responsible for any such use.


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